Graviola bark, leaves, root, and fruits have been used as traditional remedies in South America for centuries. Extracts have been shown to have antiviral, antiparasitic, antirheumatic, astringent, emetic, antileishmanial and cytotoxic effects. Graviola has also been shown to be effective against multi-drug resistant cancer cells line. Graviola seems to effectively target and kill malignant cells in more than 10 different types of cancer, including colon, breast, prostate, lung, and pancreatic cancer.
Seems to be far stronger in killing colon cancer cells than Adriamycin® (Doxorubicin hydrochloride), a chemotherapy given as treatment for certain types of cancer.
Graviola hunts down selectively- and kill cancer cells without harming healthy cells; unlike chemotherapy that indiscriminately seeks and destroys all actively reproducing cells – (even normal, healthy ones).
Research on this plant has focused on its anti-cancerous effect but the plant has been used for a long time in traditional medicine in Surinam to treat a number of ailments, such as:
hypertension, ringworm, influenza, scurvy, rashes, malaria, neuralgia, dysentery, arthritis, palpitations, rheumatism, nervousness, high blood pressure, insomnia, diarrhea, fever, nausea, boils, dyspepsia, and muscle spasm. General uses: cancer treatment, herpes, infections, parasitic infections, sedation.
Methanolic extract of Annona muricata (Annonaceae) seeds was tested for antiparasitic activity against E. histolytica, N. brasiliensis, M. dessetae and A. salina.
The acetogenins (natural chemicals) are found to be responsible for the important activity.
In a plant screening program by the National Cancer Institute, the leaves and stem of Graviola showed active cytotoxicity against cancer cells. Focus of the research was on a novel set of phytochemicals (annonaceous acetogenins).
The antitumor,properties of these annonaceous acetogenins have been reported.
Researchers reported that the Annonaceous acetogenin, bullatacin, preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate, ATP (the chief energy-carrying compound). Some of the Annonaceous acetogenins are not only effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells.
Surviving cancer cells from chemotherapy may develop resistance to the agent originally used against them as well as to other, even unrelated, drugs (multi-drug resistance or MDR). The fruit and the leaves of Annona muricata are used in traditional medicine for their tranquillizing and sedative properties.
Extracts of the plant have been shown results that imply that the fruit possesses anti-depressive effects, possibly induced by three alkaloids, annonaine (1), nomuciferine (2) and asimilobine (3), isolated from the fruit.
Dosage
From the leaves: Tincture: 1 – 4 ml. daily (1 – 4 full droppers) Infusion: 1 -3 cups daily
Precaution & contra-indications
Not be used during pregnancy due to possible uterine stimulant activity.
Contraindicated for people with low blood pressure (may posses hypotensive, vasodilator, and cardio depressant activities).
It may potentiate antidepressant drugs and interfere with MAO-inhibitor drugs.
References
Titre du document / Document title
Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT[1A] receptor agonists in rats : Unexploited antidepressive (lead) products. Auteur(s) / Author(s)
HASRAT J. A.(¹); DE BRUYNE T.(¹); DE BACKER J.-P.(²); VAUQUELIN G.(²); VLIETINCK A.(¹) Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(¹) Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, BELGIQUE.
(²) Department of Protein Chemistry, Free University of Brussels, Paardenstraat 65, 1640, St Genesius Rode, BELGIQUE.
Two New Mono-Tetrahydrofuran Ring Acetogenins, Annomuricin E and Muricapentocin, from the Leaves of Annona muricata.
Geum-soog Kim, +§Lu Zeng, +Feras Alali, +Lingling L. Rogers, +Feng-E. Wu, +Jerry L. McLaughlin,*+ and Soelaksono Sastrodihardjo± Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, and Department of Education and Culture, Center of Interuniversities, Biology Division, Bandung Institute of Technology, 10 Yanesba St., Bandung 40132, Indonesia Received November 26, 1997.
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, and Department of Education and Culture, Center of Interuniversities, Biology Division, Bandung Institute of Technology, 10 Yanesba St., Bandung 40132, Indonesia Received November 26, 1997.
The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available.
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