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| PAU D'ARCO TINCTURE (tinctura Tabebuia serratifolia) from AMAZON HERBS® |
Overview
Pau d'arco (Surinam greenheart) is a native to rainforests throughout Central- and South America.The bark contains more than 20 active compounds including lapachol, quercetin and other flavonoids. It is one of the largest and strongest of tropical forest trees, growing up to 150 feet tall while the base can be 4 to 7 feet in diameter. Traditional use It is to treat numerous conditions like bacterial and fungal infections, fever, syphilis, malaria, trypanosomiasis, as well as stomach and bladder disorders. Treatment of cancer (inhibit growth of tumors). Infections (relief of vaginal candidiasis and oral thrush candidiasis). It has antibiotic and antifungal properties and is a powerful natural antibiotic. Parasitic (intestinal parasites). Other applications are against respiratory problems and prostatitis. Part used Inner bark. Constituents Phytochemicals: Anthraquinones, Ascorbic - acid, Beta - carotene, Beta - sitosterol, Beta - lapachone (a naphthoquinone compound derived from bark of Tabebuia sp), Calcium, Chromium, Chrysophanic - acid, Cobalt, Fat, Fiber, Iron, Lapachol, Magnesium, Naphthoquinones, Niacin, Phosphorus, Potassium, Protein, Riboflavin, Selenium, Silicon, Thiamin, Zinc. Pharmacology Two main bioactive components have been isolated from Tabebuia; lapachol and ß-lapachone. ß-Lapachone is considered to be the main anti-tumour compound, in tumor and pro-apoptotic effects were observed in vitro. Some mechanistic studies on this compound's molecular effects have been conducted. The drug appears to be generally safe and one of the most important interactions of this plant has been associated with interference in the biological cycle of Vitamin K in the body. ß-lapachone inhibits DNA topoisomerase I. Topoisomerase inhibitors (including beta-lapachone) seem to be effective against several types of cancer, including lung, breast, colon and prostate cancers and malignant melanoma. Since cancer cells grow and reproduce at a much faster rate than normal cells, they are more vulnerable to topoisomerase inhibition than are normal cells. Beta-lapachone also interferes with the replication of HIV-1, a virus that causes AIDS, thereby slowing the advancement of the disease. Two drugs from the yew tree, Taxol (paclitaxel) and Taxotere (docetaxel) are currently considered to be the most important drugs in cancer chemotherapy. Both of them have shown some results in treatment of hormone refractory prostate cancer. In a preclinical new study published in Proceedings of the National Academy of Sciences, researchers at Dana-Farber Cancer Institute report that a two-drug therapy using Taxol and beta-lapachone artificially rebuilds the cell's quality-control system and can completely destroy human tumor cells grown in laboratory animals. Dosage Tincture: Children (10 years): one half of the adult doses. Children (14 years): three quarter of the adult doses. Adults: 30 drops (1 ml) ; 2 - 3 times a day in water or juice. Infusion: Boil 1 - 1½ tsp in 1 cup water (8 oz) for about 10 minutes. Drink 1 cup 2 - 3 times a day. Side effects and / or interactions Nausea and dizziness. Pau d'arco may potentiate the effects of anticoagulations / antiplatelets. Remarks Do not take while pregnant or breast feeding. References Willard T. A Textbook of Natural Medicine. Edinburgh (England): Churchill Livingstone; 1998. Oswald EH. Lapacho. Br J Phytotherapy 1994;3:112-7. Guiraud P, et al. Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Med 1994;60:373-4. Foster S, et al. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. New York: Haworth Herbal Press; 1999. Brinker F. Herb Contraindications and Drug Interactions, 2nd ed. Sandy (OR): Eclectic Med Publications; 1998. Dinnen RD, Ebisuzaki K. The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product. Anticancer Res 1997;17:1027-34. (7) Block JB, et al. Early clinical studies with lapachol. Cancer Chemother Rep 1974;4:27-8. The above presentation is for informational and educational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage. For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available. Consult your doctor, practitioner, and / or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications. |
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