The bark of this tropical tree is employed in our tinctures; it is very bitter, and is said to
be febrifuge, vermifuge (medicine that causes the expulsion of worms or parasites from the body) and anti-epileptic.
The resin from the bark is employed in bronchitis.
In traditional medicine in Suriname, it is used in the treatment of malaria and diabetes.
A quantitative ethnobotanical approach to antimalarial drug discovery led to the identification
of Lansium domesticum Corr. Ser. (Meliaceae) as an important antimalarial used by Kenyah Dyak healers in Indonesian Borneo.
Triterpenoid lansiolides with antimalarial activity were isolated from the bark and shown to have activity in both in vitro
bioassays with Plasmodium falciparum, and in mice infected with P. berghei. A survey of African and tropical American Meliaceae
led to further development of the limonoid gedunin from the traditionally used medicinal plants, tropical cedar, Cedrela odorata L.,
and neem, Azadirachta indica A. Juss. Gedunin has significant in vitro activity but initially showed poor in vivo activity.
In vivo activity was improved by:
(1) incorporation into an easy to absorb suspension, (2) preparation of a more stable compound, 7-methoxygedunin, and
(3) synergism with dillapiol, a cytochrome P450 3A4 inhibitor. The results show the potential for both
antimalarial drug and phytomedicine development from traditionally used plants.
Applications
Stomachic, tonic; for arthritis, diarrhea, dysentery, ear infections, fevers, lack of appetite,
skin ulcers, clear the lungs from mucus, malaria and diabetes.
Constituents of the leaf essential oil of Cedrela odorata L. from Nigeria.
O. T. Asekun, O. Ekundayo* Department of Chemistry, University of Ibadan, Ibadan, Nigeria
Correspondence to O. Ekundayo, Department of Chemistry, University of Ibadan, Ibadan, Nigeria Essential Oils of Toona and Cedrela Species (Meliaceae): Taxonomic and Ecological Implications
Beatriz H.L.N.S. Maia(a), José R. de Paula(a), Josué Sant'Ana(a), M. Fátima das G.F. da Silva(a),
João B. Fernandes(a), Paulo C. Vieira(a), Merilene do S.S. Costa(b), Orlando S. Ohashi(b) and José Natalino
M. Silva(c)
a Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905 São Carlos, SP, Brazil
b Faculdade de Ciéncias Agrárias do Pará, Belém, PA, Brazil
c Empresa Brasileira de Pesquisa Agropecuária, Belém, PA, Brazil
The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter medication is also available.
Consult your doctor, practitioner, and / or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications.
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